Cytokines and Joint Injury by Wim B. van den Berg (English) Paperback Book

Description: Cytokines and Joint Injury by Wim B. van den Berg, Pierre Miossec The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology. Table of Contents The role of tumour necrosis factor in rheumatoid arthritis.- The IL-1 family: the role of IL-1 and IL-18 in inflammation.- Targeted IL-1 inhibition.- Is IL-6 a therapeutic target?.- The clinical use of anti-cytokine therapy in rheumatic diseases.- Innate response cytokines in inflammatory synovitis: interleukin-15 and interleukin-18.- IL-17 as a contributor to inflammation and destruction in rheumatoid arthritis.- Cell-cell contact in chronic inflammation: the importance to cytokine regulation in tissue destruction and repair.- The role of proteinases in joint tissue destruction.- Receptor activator of nuclear factor KB ligand (RANKL) versus osteoprotegerin (OPG): the yin and yang of joint integrity.- Cytokine regulation of bone destruction. Promotional Springer Book Archives Long Description The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe Feature Gives a balanced view on central cytokines and joint pathology International authorship Description for Sales People This topical insight in the role of cytokines in joint inflammation and destruction helps to better understand key processes in diseases such as rheumatoid arthritis and osteoarthritis. Apart from the impact of cytokines on joint tissues, various chapters address targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay, and mechanisms of cartilage destruction and bone erosion. New information on the cytokines IL-15, IL-17 and IL-18 and their position in the complex cytokine interplay and an outline of the role of established cytokines, such as TNF, IL-1 and IL-6, is provided. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles in joint erosion are highlighted. This volume gives a complete and balanced view on pivotal cytokines and joint pathology for the biomedical and clinical researcher. Details ISBN3034896093 Series Progress in Inflammation Research Year 2012 ISBN-10 3034896093 ISBN-13 9783034896092 Format Paperback Publication Date 2012-10-23 Country of Publication Switzerland Edited by Wim B. van den Berg DEWEY 571.6 Language English Media Book Short Title CYTOKINES & JOINT INJURY SOFTC Pages 296 Illustrations XI, 296 p. Publisher Birkhauser Verlag AG Imprint Birkhauser Verlag AG Place of Publication Basel Author Pierre Miossec Edition Description Softcover reprint of the original 1st ed. 2004 Alternative 9783764370015 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96374214;

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