Cytokines and Pain by L.R. Watkins (English) Hardcover Book

Description: Cytokines and Pain by L.R. Watkins, S.F. Maier These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans. Table of Contents Overview of inflammatory cytokines and their role in pain.- Evolutionary perspectives of cytokines in pain.- Illness-induced hyperalgesia: Mediators, mechanisms and implications.- Hyperalgesia from subcutaneous cytokines.- Cytokine-nerve growth factor interactions in inflammatory hyperalgesia.- Hyperalgesic actions of cytokines on peripheral nerves.- Proinflammatory cytokines and glial cells: Their role in neuropathic pain.- Brain cytokines and pain.- Interleukin-1 and tumor necrosis factor: Rheumatoid arthritis and pain. Promotional Springer Book Archives Details ISBN3764358491 Language English ISBN-10 3764358491 ISBN-13 9783764358495 Media Book Format Hardcover Imprint Birkhauser Verlag AG Place of Publication Basel Country of Publication Switzerland Short Title CYTOKINES & PAIN 1999/E Pages 232 Birth 1954 Edition 1999th DOI 10.1007/b70524;10.1007/978-3-0348-8749-6 Edited by Maier, S. F. Author S.F. Maier Publisher Birkhauser Verlag AG Edition Description 1999 ed. Series Progress in Inflammation Research Year 1998 Publication Date 1998-12-07 Alternative 9783034897563 DEWEY 616.0472 Illustrations VIII, 232 p. Audience Undergraduate We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96251016;

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