Description: Evaluation of Drug Candidates for Preclinical Development : Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology, Hardcover by Han, Chao (EDT); Davis, Charles B. (EDT); Wang, Binghe (EDT), ISBN 0470044918, ISBN-13 9780470044919, Like New Used, Free P&P in the UK Aiming to aid in the formulation of drug development strategies, eleven chapters are presented by Han (pharmacokinetics and clinical pharmacology sciences, Centocor R&D), Davis (Center for Metabolism Drug Discovery Unit, Cancer Research, GlaxoSmithKline), and Wang (drug discovery and chemistry, Georgia State U.) dealing with the key areas of pharmacokinetics and drug metabolism, pharmaceutical development, and safety assessment. The goal is to stress the integration of activities and information essential for the advancement of new medicines during drug development. The chapters specifically address pharmacokinetics in preclinical drug development, the role of membrane transporters in drug dispostion, cytochrome P450 and its application in drug discovery and development, the role of drug metabolism and metabolite identification in drug discovery, protein binding in drug discovery and development, prediction of pharmacokinetics in humans, pharmaceutics developability assessment, safety assessment in drug discovery, and assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and the associated tachyarrhythmia known as Torsade de Pointes. Annotation ©2010 Book News, Inc., Portland, OR ()
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Book Title: Evaluation of Drug Candidates for Preclinical Development : Pharm
Number of Pages: 304 Pages
Language: English
Publication Name: Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology
Publisher: John Wiley & Sons INC International Concepts
Publication Year: 2010
Subject: Medicine
Item Height: 241 mm
Item Weight: 570 g
Type: Textbook
Author: Binghe Wang, Charles B. Davis, Chao Han
Series: Wiley Series in Drug Discovery and Development
Item Width: 163 mm
Format: Hardcover