Description: Innate Immune Regulation and Cancer Immunotherapy Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Author(s): Rong-Fu Wang Format: Hardback Publisher: Springer-Verlag New York Inc., United States Imprint: Springer-Verlag New York Inc. ISBN-13: 9781441999139, 978-1441999139 Synopsis Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.
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Book Title: Innate Immune Regulation and Cancer Immunotherapy
Number of Pages: 478 Pages
Language: English
Publication Name: Innate Immune Regulation and Cancer Immunotherapy
Publisher: Springer-Verlag New York Inc.
Publication Year: 2011
Subject: Medicine
Item Height: 235 mm
Item Weight: 893 g
Type: Textbook
Author: Rong-Fu Wang
Item Width: 155 mm
Format: Hardcover