Integrative Physiology in the Proteomics and Post-Genomics Age by Wolfgang Walz

Description: Integrative Physiology in the Proteomics and Post-Genomics Age by Wolfgang Walz This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description This collection of articles by internationally recognized researchers highlights the major questions and accomplishment of modern physiological research and demonstrates that modern molecular methods can well be incorporated and strengthen the original integrative perspectives of physiology set out by Claude Bernards concept of the "milieu interieur." Among the critical issues discussed are the place of functional genomics in regulatory physiology, the role of model systems in integrative physiology, the function of neural circuits in behavior and consciousness, and the influence of external challenges to the whole body and the environment on genes. Perceptive and timely, Integrative Physiology in the Proteomics and Post-Genomics Age bridges the gap between molecular biology and whole body function, establishing the future of physiology as an integrative science based on new molecular insights. Back Cover The advent of molecular techniques has shifted the focus of physiology from its traditional role as an integrative science concerned with the study of regulatory mechanisms leading to adaptation and homeostasis, to a field preoccupied with the problems and challenges inherent in those techniques. In Integrative Physiology in the Proteomics and Post-Genomics Age, internationally recognized researchers highlight the major questions and accomplishments of modern physiological research and demonstrate that modern molecular methods can well be incorporated and strengthen the original integrative perspectives of physiology set out by Claude Bernards concept of the "milieu interieur." Among the critical issues discussed are the place of functional genomics in regulatory physiology, the role of model systems in integrative physiology, the function of neural circuits in behavior and consciousness, and the influence of external challenges to the whole body and the environment on genes. The question of integrative physiology in curriculum design for the health sciences is also discussed. Perceptive and timely, Integrative Physiology in the Proteomics and Post-Genomics Age bridges the gap between molecular biology and whole body function, establishing the future of physiology as an integrative science based on new molecular insights. Table of Contents From Functional Linkage to Integrative Physiology.- Functional Genomics.- Electrolytes and Acid-Base Physiology.- Circulation and Fluid Volume Control.- Neuroendocrine Networks.- Physiology and Behavior.- Neural Circuits and Behavior.- Physiological Determinants of Consciousness.- Physical Activity.- Biochemical Adaptation to Extreme Environments.- Repair and Defense Systems at the Epithelial Surface in the Lung.- The Zebrafish As an Integrative Physiology Model.- Curriculum Design for Integrative Physiology. Review From the reviews: "This book, authored by 19 expert contributors, introduces its reader to that fresh enlightening viewpoint. It should help design curricula and identify learning objectives of both medical students and professional physiologists. ! As a conclusion, this book represents the leading edge of an exciting development in biological science: the re-emergence of integrative physiology as an organizing principle. I agree." (William H. Wehrmacher, Trends in Endocrinology and Metabolism, Vol. 17 (5), 2006) Long Description There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernards concept of the "milieu interieur," Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism. Review Quote From the reviews:"This book, authored by 19 expert contributors, introduces its reader to that fresh enlightening viewpoint. It should help design curricula and identify learning objectives of both medical students and professional physiologists. As a conclusion, this book represents the leading edge of an exciting development in biological science: the re-emergence of integrative physiology as an organizing principle. " I agree." (William H. Wehrmacher, Trends in Endocrinology and Metabolism, Vol. 17 (5), 2006) Feature Includes supplementary material: sn.pub/extras Details ISBN1617374881 Short Title INTEGRATIVE PHYSIOLOGY IN THE Language English ISBN-10 1617374881 ISBN-13 9781617374883 Media Book Format Paperback Year 2010 Edition 1st Imprint Humana Press Inc. Place of Publication Totowa, NJ Country of Publication United States Edited by Wolfgang Walz DEWEY 612.0072 Pages 269 Illustrations X, 269 p. Publication Date 2010-11-05 AU Release Date 2010-11-05 NZ Release Date 2010-11-05 US Release Date 2010-11-05 UK Release Date 2010-11-05 Author Wolfgang Walz Publisher Humana Press Inc. Edition Description Softcover reprint of hardcover 1st ed. 2005 Alternative 9781588293152 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! 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