Description: Further DetailsTitle: Dementia, Diabetes, and HypertensionCondition: NewSubtitle: Is There a Unified Theory through a Dysregulation of the Ca2+ Homeostasis?ISBN-10: 1536192279EAN: 9781536192278ISBN: 9781536192278Publisher: Nova Science Publishers IncFormat: PaperbackRelease Date: 02/17/2021Language: EnglishCountry/Region of Manufacture: USItem Height: 230mmItem Length: 155mmItem Weight: 256gAuthor: Leandro Bueno BergantinGenre: MedicineDescription: Dementia, diabetes, and hypertension are considered huge medical problems around the world, costing many millions of dollars to the medical health systems. Curiously, hypertension has been clinically linked with a higher risk for decline of cognition, as shown in dementia patients. In addition, there is a clear clinical association between hypertension and diabetes, reflecting substantial similarities in their aetiology. In fact, consistent data support that patients diagnosed with diabetes have shown an increased risk of presenting cognitive dysfunctions, clinical signs of dementia. Considering the cumulative knowledge from the scientific literature, we can now link Ca2+ signals dysregulations as an upstream issue for hypertension, diabetes and other inflammatory processes, and dementia. Regarding therapeutics, hypertensive patients have been classically treated with Ca2+ channel blockers (CCBs), medicines whose mechanism of action consists in reducing the influx of Ca2+ into the cells. Intriguingly, many clinical reports have been demonstrating off-label effects for CCBs. In hypertensive patients treated with CCBs, it can be observed a lower incidence of dementia such as Alzheimer's disease. The possible mechanism of action could be attributed to a restoration of the Ca2+ homeostasis. In addition, in hypertensive patients treated with CCBs, it can be also observed an improvement of diabetes status such as glycaemic control. A possible mechanism of action could be due to a restoration of insulin secretion, then achieving glycaemic control, and a reduction of the pancreatic β-cell apoptosis. Thus, this book puts together fundamental concepts, and current therapies to treat dementia, hypertension, and diabetes, including novel therapeutics coming from the pharmacological manipulation of Ca2+/cAMP signalling. Finally, this book compiles more than 300 references from the scientific literature, including data of high evidence such as meta-analysis and systematic reviews, and discusses pharmaceuticals already approved and clinically safe, e.g., CCBs, then allowing sustained increments in the life quality of age-related patients.Release Year: 2021 Missing Information?Please contact us if any details are missing and where possible we will add the information to our listing.
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Book Title: Dementia, Diabetes, and Hypertension
Title: Dementia, Diabetes, and Hypertension
Subtitle: Is There a Unified Theory through a Dysregulation of the Ca2+ Hom
ISBN-10: 1536192279
EAN: 9781536192278
ISBN: 9781536192278
Release Date: 02/17/2021
Release Year: 2021
Country/Region of Manufacture: US
Item Height: 230mm
Genre: Medicine
Number of Pages: 155 Pages
Publication Name: Dementia, Diabetes, and Hypertension: Is There a Unified Theory Through a Dysregulation of the Ca2+ Homeostasis?
Language: English
Publisher: NOVA Science Publishers, Incorporated
Publication Year: 2021
Subject: General, Internal Medicine
Item Weight: 9 Oz
Type: Textbook
Item Length: 9.1 in
Author: Leandro Bueno Bergantin
Subject Area: Medical
Item Width: 6.1 in
Series: Research Progress in Alzheimer's Disease and Dementia Ser.
Format: Trade Paperback
