New Trends in Lipid Mediators Research Vol. 5 Eye Inflammation N.G.Bazan Karger

Description: Lipid Mediators in Eye Inflammation Editor: N.G. Bazan, New Orleans, La. X + 192 p., 38 fig., 18 tab., hard cover, 1990. ISBN 3-8055-5067-7 The ocular inflammatory response involves an array of chemical mediators among which lipid mediators comprise a structurally heterogeneous group with diverse and potent effects. Generated by the need to identify the chemical and cellular events in various forms of eye inflammation, this volume represents the coordinated efforts of key researchers to compile the most recent discoveries concerning the role of lipid mediators. Invited contributions consider the relationship between lipid mediators - leukotrienes, thromboxanes, prostaglandins and platelet-activating factor - and inflammation in experimental models and pathological conditions. Potential therapeutic agents are discussed, including second-generation leukotriene-receptor antagonists, 5-lipoxygenase inhibitors and PAF antagonists, which will open up new approaches for the clinical management of various forms of eye inflammation hitherto elusive to therapy. In addition, the effects of dietary fatty acids on inflammation, and the role of lipid mediators in gene expression and cellular proliferation are examined. Reflecting the tremendous growth of knowledge and interest in lipid mediators research, this monograph is compulsory reading for ophthalmic researchers, allergists, immunologists and biochemists wishing to keep up to date with advances in this dynamic field.

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