Phagocytosis of Dying Cells: From Molecular Mechanisms to Human Diseases by Dmit

Description: Phagocytosis of Dying Cells by Dmitri V. Krysko, Peter Vandenabeele This comprehensive volume covers the immunological, molecular and biological aspects of phagocytosis of dying cells as well as its clinical relevance. It integrates the latest research from many related disciplines of science and includes 59 illustrations. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Phagocytosis has been at the forefront of cell biology for more than a century. Initially, phagocytosis, which comes from Greek words meaning "devouring cells," was discovered in the late 19th century by Ilya Metchnikoff, who was awarded, together with Paul Ehrlich, the Nobel Prize in Physiology and Medicine in 1908 "in recognition of their work on immunity." At that time Metchnikoff had already identified a function for phagocytes not only in host defense but also as scavengers of degenerating host cells during metamorphosis of tadpoles, thus providing one of the first descriptions of apoptotic cell clearance by macrophages (Kaufmann 2008). Since then, much has been learned about phagocytosis, and the previous several decades have witnessed outstanding progress in understanding the functions and the molecular mechanisms of phagocytosis. Two main types of targets are cleared by phagocytosis: microbial pathogens and dying cells. Rapid recognition and clearance of dying cells by phagocytes plays a pivotal role in development, maintenance of tissue homeostasis, control of immune responses, and resolution of inflammation. Clearance of dying cells can be divided into several stages, including sensing, r- ognition, binding and signaling, internalization, and immunological responses. In this book, our contributors address these different stages of dead cell cle- ance and examine how impaired clearance of dying cells may lead to human d- eases. We have attempted to provide sufficient cross-referencing and indexing to enable the reader to easily locate the ideas elaborated in the different chapters. Notes The first book on this subjectDevoted to describing the molecular mechanisms of phagocytosis of dying cells and examining the impact of defective clearance of dying cells on the immune function and development of human diseasesWill be of great interest and value for students in medical, biomedical and biotechnological faculties and for researchers in biotechnological companies and of particular interest to cell biologists, immunologists and cliniciansAlso gives an overview of the molecular pathways of apoptosis, necrosis and autophagy, as well as of the methods available for studying their clearanceIncludes 59 illustrations (40 in color) to facilitate easy and clear understanding of what are sometimes quite complex phenomenaContains sufficient cross-referencing and indexing to enable the reader to easily locate the sources or origins of the ideas elaborated in the different chapters Table of Contents Molecular Mechanisms of Phagocytosis of Dying Cells.- Molecular Pathways of Different Types of Cell Death: Many Roads to Death.- Apoptotic, Autophagic and Necrotic Cell Death Types in Pathophysiological Conditions: Morphological and Histological Aspects.- Role of Attraction and Danger Signals in the Uptake of Apoptotic and Necrotic Cells and its Immunological Outcome.- Molecules Involved in Recognition and Clearance of Apoptotic/Necrotic Cells and Cell Debris.- Evolutionarily Conserved Pathways Regulating Engulfment of Apoptotic Cells.- Innate Apoptotic Immunity: A Potent Immunosuppressive Response Repertoire Elicited by Specific Apoptotic Cell Recognition.- Comparative Characterization of Non-professional and Professional Phagocyte Responses to Apoptotic Cells.- Methods Used to Study Apoptotic Cell Clearance.- Impairment of Phagocytosis of Dying Cells and its Role in the Development of Diseases.- Results of Defective Clearance of Apoptotic Cells: Lessons from Knock-out Mouse Models.- Clearance of Dying Cells and Systemic Lupus Erythematosus.- Apoptotic Cells for Therapy of Transplant Rejection.- Impact of Tumour Cell Death on the Activation of Anti-tumour Immune Response.- Phagocytosis of Dying Cells in the Pathogenesis of Atherosclerosis.- The Impact of Defective Clearance of Apoptotic Cells in the Pathogenesis of Chronic Lung Diseases: Chronic Obstructive Pulmonary Disease, Asthma and Cystic Fibrosis.- Environmental Factors Affecting Phagocytosis of Dying Cells:Smoking and Static Magnetic Fields. Long Description Phagocytosis has been at the forefront of cell biology for more than a century. Initially, phagocytosis, which comes from Greek words meaning "devouring cells," was discovered in the late 19th century by Ilya Metchnikoff, who was awarded, together with Paul Ehrlich, the Nobel Prize in Physiology and Medicine in 1908 "in recognition of their work on immunity." At that time Metchnikoff had already identified a function for phagocytes not only in host defense but also as scavengers of degenerating host cells during metamorphosis of tadpoles, thus providing one of the first descriptions of apoptotic cell clearance by macrophages (Kaufmann 2008). Since then, much has been learned about phagocytosis, and the previous several decades have witnessed outstanding progress in understanding the functions and the molecular mechanisms of phagocytosis. Two main types of targets are cleared by phagocytosis: microbial pathogens and dying cells. Rapid recognition and clearance of dying cells by phagocytes plays a pivotal role in development, maintenance of tissue homeostasis, control of immune responses, and resolution of inflammation. Clearance of dying cells can be divided into several stages, including sensing, r- ognition, binding and signaling, internalization, and immunological responses. In this book, our contributors address these different stages of dead cell cle- ance and examine how impaired clearance of dying cells may lead to human d- eases. We have attempted to provide sufficient cross-referencing and indexing to enable the reader to easily locate the ideas elaborated in the different chapters. Feature The first book on this subject Devoted to describing the molecular mechanisms of phagocytosis of dying cells and examining the impact of defective clearance of dying cells on the immune function and development of human diseases Will be of great interest and value for students in medical, biomedical and biotechnological faculties and for researchers in biotechnological companies and of particular interest to cell biologists, immunologists and clinicians Also gives an overview of the molecular pathways of apoptosis, necrosis and autophagy, as well as of the methods available for studying their clearance Includes 59 illustrations (40 in color) to facilitate easy and clear understanding of what are sometimes quite complex phenomena Contains sufficient cross-referencing and indexing to enable the reader to easily locate the sources or origins of the ideas elaborated in the different chapters Details ISBN140209292X Short Title PHAGOCYTOSIS OF DYING CELLS Pages 447 Language English ISBN-10 140209292X ISBN-13 9781402092923 Media Book Format Hardcover Year 2009 Edited by Dmitri V. Krysko Imprint Springer-Verlag New York Inc. Place of Publication New York, NY Country of Publication United States Subtitle From Molecular Mechanisms to Human Diseases Edition 2009th DOI 10.1007/978-1-4020-9293-0 AU Release Date 2009-01-14 NZ Release Date 2009-01-14 US Release Date 2009-01-14 UK Release Date 2009-01-14 Author Peter Vandenabeele Publisher Springer-Verlag New York Inc. Edition Description 2009 ed. Publication Date 2009-01-14 Alternative 9789401782999 DEWEY 616.0799 Illustrations X, 447 p. Audience Postgraduate, Research & Scholarly We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96312293;

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