Rigor and Reproducibility in Genetics and Genomics: Peer-reviewed, Published, Ci

Description: Rigor and Reproducibility in Genetics and Genomics by George P. Patrinos, Douglas F. Dluzen, Monika Schmidt Rigor and Reproducibility in Genetics and Genomics: Peer-reviewed, Published, Cited provides a full methodological and statistical overview for researchers, clinicians, students, and post-doctoral fellows conducting genetic and genomic research.Here, active geneticists, clinicians, and bioinformaticists offer practical solutions for a variety of challenges associated with several modern approaches in genetics and genomics, including genotyping, gene expression analysis, epigenetic analysis, GWAS, EWAS, genomic sequencing, and gene editing. Emphasis is placed on rigor and reproducibility throughout, with each section containing laboratory case-studies and classroom activities covering step-by-step protocols, best practices, and common pitfalls. Specific genetic and genomic technologies discussed include microarray analysis, DNA-seq, RNA-seq, Chip-Seq, methyl-seq, CRISPR gene editing, and CRISPR-based genetic analysis. Training exercises, supporting data, and in-depth discussions of rigor, reproducibility, and ethics in research together deliver a solid foundation in research standards for the next generation of genetic and genomic scientists. FORMAT Paperback LANGUAGE English CONDITION Brand New Author Biography George P. Patrinos is a Professor of Pharmacogenomics and Pharmaceutical Biotechnology in the University of Patras (Greece), Department of Pharmacy, and Head of Division of Pharmacology and Biosciences of the same department and holds adjunct Full Professorships at Erasmus MC, Faculty of Medicine, and Health Sciences, Rotterdam (the Netherlands), and the United Arab Emirates University, College of Medicine, Department of Genetics and Genomics, Al-Ain (UAE). Also, from 2018 until the end of 2024, he was Chair of the Global Genomic Medicine Collaborative (G2MC). He served 12.5 years as a full member and Greeces National representative in the CHMP Pharmacogenomics Working Party of the European Medicines Agency (EMA). George has more than 340 publications in peer-reviewed scientific journals, some of them in leading scientific journals, such as The Lancet, Nature Genetics, Nature Reviews Genetic, Nucleic Acids Research, Genes & Development. He has also coauthored and coedited more than 15 textbooks, among which the renowned textbook Molecular Diagnostics, published by Academic Press, now in its 3rd edition, while he is the editor of Translational and Applied Genomics book series, published by Elsevier. Furthermore, he serves as the Editor-In-Chief of the prestigious Pharmacogenomics Journal (TPJ), published by Nature Publishing Group, Associate Editor, and member of the editorial board of several scientific journals, and advisory and evaluation committees. Apart from that, George is the main coorganizer of the Golden Helix Conferences, an international meeting series on Pharmacogenomics and Genomic Medicine with more than 50 conferences organized in more than 25 countries worldwide.Douglas F. Dluzen is a geneticist and has previously studied the genetic contributors to aging, drug metabolism, hypertension, and inflammation. Dluzen is particularly interested in how social determinants of health influence gene expression in the immune system. Currently, he is the director of the Professional Development and Career Office at the Johns Hopkins University School of Medicine and has worked previously at the National Institutes of Health and Morgan State University. He enjoys writing science fiction and hiking with his family.Monika Schmidt completed her doctoral work in the realm of tandem repeat-associated neuromuscular/neurodegenerative diseases, with a focus upon fragile X syndrome, amyotrophic lateral sclerosis, and DNA metabolism. Monika has a particular interest in wet lab validation of in silico findings, with a penchant for Southern blotting of structurally complex repetitive DNA sequences. Currently, she is a freelance scientific editor, private healthcare liaison, and event organizer. Monika enjoys traveling on a shoestring, working with her hands on home or cottage improvements, and spending time with her spouse and children. Table of Contents SECTION 1 Introduction 1. Rigor and reproducibility in genetic research and the effects on scientific reporting and public discourse 2. Unveiling the hidden curriculum: Developing rigor and reproducibility values through teaching and mentorship SECTION 2 Genotyping 3. Genome-wide association studies (GWAS): hat are they, when to use them? 4. GWAS in the learning environment 5. Polygenic risk scores and comparative genomics: Best practices and statistical considerations 6. DNA sequencing and genotyping in the classroom 7. Classroom to career: Implementation considerations for engaging students with meaningful DNA sequencing learning opportunities SECTION 3 Next-generation sequencing & gene expression 8. Review of gene expression using microarray and RNA-seq 9. Guidelines and important considerations for omics-level studies 10. Best practices for statistical analysis of omics data 11. Validation of gene expression by quantitative PCR SECTION 4 Epigenetic analyses 12. Best practices for epigenome-wide DNA modification data collection and analysis 13. Best practices for the ATAC-seq assay and its data analysis 14. Best practice for ChIP-seq and its data analysis 15. A practical guide for essential analyses of Hi-C data 16. Epigenetics in the classroom SECTION 5 Gene editing technologies 17. Genome editing technologies 18. Genetic modification of mice using CRISPR-Cas9: Best practices and practical concepts explained 19. CRISPR classroom activities and case studies Feature Provides practical approaches and step-by-step protocols to strengthen genetic and genomic research conducted in the lab or classroom Through illustrative case studies and training exercises, discusses common pitfalls and solutions for genotyping, gene expression analysis, epigenetic analysis, GWAS, EWAS, genomic sequencing, and gene editing, among other genetic and genomic approaches Specifically examines best practices for microarray analysis, DNA-seq, RNA-seq, gene expression validation, Chip-Seq, methyl-seq, CRISPR gene editing, and CRISPR-based genetic analysis Details ISBN0128172185 Short Title Rigor and Reproducibility in Genetics and Genomics Series Translational and Applied Genomics Language English ISBN-10 0128172185 ISBN-13 9780128172186 Format Paperback Place of Publication San Diego Country of Publication United States UK Release Date 2023-10-01 Author Monika Schmidt Publisher Elsevier Science Publishing Co Inc Year 2023 Imprint Academic Press Inc Subtitle Peer-reviewed, Published, Cited Alternative 9780128172193 DEWEY 610.285 Audience Professional & Vocational NZ Release Date 2023-10-24 Pages 502 Publication Date 2023-11-09 US Release Date 2023-11-09 Illustrations 50 illustrations (20 in full color); Illustrations AU Release Date 2023-11-08 We've got this At The Nile, if you're looking for it, we've got it. 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